"Sakura Sakura" (Cherry blossoms, cherry blossoms) is a biopic about Dr. Jokichi Takamine (1854-1922), the late biochemist known for successfully crystallizing and isolating adrenaline, which is also called epinephrine.Dubbed the father of modern biotechnology, Takamine also produced Takadiastase, a digestive enzyme still used as an ingredient in medicines.He could never have made the groundbreaking achievements without his American wife, Caroline Hitch.The subtitled film, "Samurai Kagakusha Takamine Jokichi no Shogai" (Life of samurai chemist Jokichi Takamine), depicts his life during turbulent times both in Japan and the United States.The story begins at a medical center in today's Kanazawa, capital of Ishikawa Prefecture, when a patient is brought in for emergency care. During the operation, a doctor calls a hemostatic agent "epinephrine."After the surgery, a nurse insists the agent should be properly called "adrenaline."She is Mariko (Sachiko Kokubu), a great-granddaughter of Takamine's younger sister. She is frustrated because she thinks Takamine is not fairly evaluated in Japan.In 1883, Takamine (Masaya Kato) returns to Japan after studying in Britain. Takamine tells his father he wants to be a chemist, not a medical doctor like his father. He explains he wants to save the lives of tens of thousands of people.He visits New Orleans, where the 30-year-old falls in love with an 18-year-old girl named Caroline (Naomi Grace).It is not easy for the couple to enter into an international marriage, especially when more than 100 years ago, they were quite uncommon.They have their ups and downs, but never give up and continue to devote great energy to their work. Takamine was also enthusiastic about establishing friendly relations between Japan and the United States. He was responsible for a gift of 3,000 cherry trees in the U.S. capital, Washington D.C.Veteran actor Kato plays Takamine, while jazz pop singer Grace makes her screen debut as Caroline. Director Toru Ichikawa has directed 68 films and written 22 scripts.Directed by Toru Ichikawa, starring Masaya Kato, Naomi Grace and Sachiko Kokubu; opening March 5 at theaters in Tokyo, Yokohama and Chiba, to be followed by theaters nationwide